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mavorixafor will raise the level or effect of codeine by impacting hepatic enzyme CYP2D6 metabolism. Contraindicated. Mavorixafor (a robust CYP2D6 inhibitor) is contraindicated with drugs which can be hugely depending on CYP2D6 for clearance.Intense Allergic Reactions. Dextromethorphan may possibly trigger allergic reactions, which can be serious.